This is the key difference between interferon beta 1a and interferon beta 1b. Combining therapies with interferon beta for relapsing and early. Interferon beta 1ainduced severe autoimmune hepatitis. Clinical history, laboratory tests, imaging studies and liver biopsy revealed no. Avonex interferon beta1a is indicated for the treatment of patients with relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations.
This information does not take the place of talking with your healthcare provider about your medical condition or your treatment. Novartis pivotal data show children and adolescents with. Pdf two recombinant human interferonbeta 1a pharmaceutical. Interferon beta exerts its biological effects by binding to specific receptors on the surface of human cells.
Interferon beta1a rebif is a protein produced by recombinant dna technology using genetically engineered chinese hamster ovary cells into which the human interferon beta genes have been introduced. Interferon beta 1a an overview sciencedirect topics. Interferon beta is used commonly to prevent relapses in multiple sclerosis. Costeffectiveness of different interferon beta products for relapsing. Interferon beta1a is an immunologic adjuvant that is fda approved for the treatment of multiple sclerosis. Interferon beta 1a intramuscular injection is used to treat adults with various forms of multiple sclerosis ms. Limited published literature has described the presence of interferon beta1a products in human milk at low levels. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Avonex is contraindicated in patients with a history of hypersensitivity to natural or recombinant interferon beta, or any other component of the formulation see warnings and precautions 5.
This page is intended for us healthcare professionals. Food and drug administration has approved plegridy peginterferon beta1a, biogen idec as a new diseasemodifying therapy for people with relapsing forms of ms. Interferon beta 1a and interferon beta 1b are not interchangeable. Also beta interferon is coded by a gene docked on human. Apr 09, 2020 interferon beta 1a may also be used for purposes not listed in this medication guide.
Pdf subcutaneous interferon beta1a in pediatric multiple. Overview beta interferons and glatiramer acetate for. Unusual side effects of interferon beta1a in patient with. Relatively few headtohead studies have been conducted among the brace therapies and discussion here is confined to those involving ifn beta 1b. Avonex interferon beta1a is indicated for the treatment of relapsing forms of multiple sclerosis ms, to include clinically isolated syndrome, relapsingremitting disease, and active secondary progressive disease, in adults. Therefore determining of costeffectiveness interferon beta inf. Avonex, rebif interferon beta 1a dosing, indications. Interferon beta1b article about interferon beta1b by. Nov 22, 2004 safety study of interferon beta 1a to for acute stroke the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Read the medication guide and instructions for use provided by your pharmacist before you start using interferon beta1a and each time you get a refill. Interferon beta1a article about interferon beta1a by the. Clinical results of a multicenter,randomized, doubleblind, placebocontrolled trial.
Jun 27, 2018 this guidance replaces nice technology appraisal guidance on beta interferon and glatiramer acetate for the treatment of multiple sclerosis ta32. Fda approves plegridy pegylated interferon beta for. A major cytogenetic response is defined by nov 22, 2004. Interferon beta1b is a cytokine in the interferon family used to treat the relapsingremitting and secondaryprogressive forms of multiple sclerosis ms.
Avonex interferon beta1a is a prescription medicine used to treat relapsing forms of multiple sclerosis ms, to include clinically isolated syndrome, relapsingremitting disease, and active secondary progressive disease, in adults. Interferon beta1a induces expression of brainderived neurotrophic. In addition to laboratory tests normally required for monitoring patients with multiple sclerosis, complete blood and differential white blood cell counts, platelet counts and blood chemistries, including liver function tests, are recommended at regular intervals one, three, and six months following introduction of interferon 1b therapy, and. Interferon beta is a well known cause of mild hepatic injury that occasionally can lead. Side effects include flulike symptoms muscle aches, fever, chills and. Costeffectiveness of interferon beta1a, interferon beta1b, and. Get emergency medical help if you have signs of an allergic reaction hives, itching, anxiety, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat. A small preliminary study suggests that in patients who develop serum neutralizing antibodies to the interferon beta drug they use, switching to an alternate interferon beta preparation may not be clinically beneficial. These records are from cders historical file of information previously disclosed under the freedom of information act foia for this drug approval and are. Interferon beta1a is designed to be identical to interferon beta that is naturally produced by various cells in the body. Rebif interferon beta1a is formulated as a sterile solution in a prefilled syringe or rebif 17.
Interferon beta 1a induced severe autoimmune hepatitis. A 41yearold man with a history of autologous stemcell transplantation received interferon beta 1a for multiple sclerosis. In the treatment of multiple sclerosis which is a demyelinating disease, interferon beta1a and interferon beta. Current perspectives on interferon beta1b for the treatment. Dailymed rebif interferon beta1a kit rebif rebidose. Interferon beta1a multiple sclerosis discovery forum. Interferon beta 1a rebif is administered subcutaneously at the same time preferably late in the afternoon or evening on the same days of the week at least 48 hours apart. Interferon beta 1a definition of interferon beta 1a by. Avonex interferon beta1a is indicated for the treatment of patients with relapsing forms of multiple sclerosis to slow the accumulation of physical disability and. If a dose is missed, administer the dose as soon as possible then skip the following day. Your responsibility the recommendations in this guidance represent the view of nice, arrived at after careful consideration of the evidence available. Interferon beta in multiple sclerosis journal of neurology.
In the model, all patients start in the health state stage of edss. Avonex interferon beta1a side effects, images, uses. Safety study of interferon beta 1a to for acute stroke full. Clinical, radiological and electrophysiological comparison of immunomodulatory therapies in multiple sclerosis. There is yet no solid evidence it provides any benefit against the sarsncov2 virus that causes the deadly respiratory pandemic, but studies are ongoing. Rebif interferon beta1a dose, indications, adverse effects. The first interferon ever discovered is the beta type, which was first observed by isaacs and lindenmann. After 18 months of treatment, he developed persistent hematuria and 1 month later developed large ecchymoses, and bleeding from puncture sites. The recommended dose of rebif is either 22 mcg or 44 mcg injected subcutaneously three.
For use in multiple sclerosis, interferon beta 1a is injected into the muscle intramuscular injection, and beta 1b is injected just below the skin subcutaneous injection. Several pharmacodynamic properties explain the immunomodulatory actions of inf. Using a reference standard calibrated against the world health organization natural interferon beta standard second international standard for interferon, human fibroblast gb 23 902 531, rebif has a specific activity of approximately 270 million international units miu of antiviral activity per mg of interferon beta1a determined. Interferon beta2 definition of interferon beta2 by. Everyotherday interferon beta 1b versus onceweekly interferon beta 1a for multiple sclerosis. Interferon beta1a rebif is administered subcutaneously at the same time preferably late in the afternoon or evening on the same days of the week at least 48 hours apart. The most common side effects of interferons are flulike symptoms such as headaches, muscle aches, joint aches, feverschills and feeling sick, vomiting.
Read the medication guide and instructions for use provided by your pharmacist before you start using interferon beta 1a and each time you get a refill. Listing a study does not mean it has been evaluated by the u. The efficacy of interferon beta 1a has not been demonstrated beyond 4 years. Avonex interferon beta 1a is indicated for the treatment of patients with relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations. Get emergency medical help if you have signs of an allergic reaction hives, itching, anxiety, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling. Rebif interferon beta1a is contraindicated in patients with a history of hypersensitivity to natural or recombinant interferon, human albumin, mannitol usp.
Side effects include flulike symptoms muscle aches, fever, chills and malaise for 2448 hours after injection. Interferon beta1b solution, reconstituted recon soln. Interferon beta is associated with the formation of neutralizing antibodies. Some claims have been made that interferons produce about an 1838% reduction in the rate of ms relapses. Three different drugs containing interferon beta1a have been developed and are marketed in most englishspeaking countries under the trade names rebif1,2, avonex3,4 and plegridy5,6. Interferon beta 1b is a cytokine in the interferon family used to treat the relapsingremitting and secondaryprogressive forms of multiple sclerosis ms. Two forms of interferon beta are used in the treatment of ms. Novartis pivotal data show children and adolescents with relapsing ms had an 82% lower relapse rate with fingolimod vs. Closely related is interferon beta 1a, also indicated for ms, with a very similar drug profile. Interferon beta1a should be used during pregnancy and lactation only if the benefit justifies the potential.
How to use interferon beta1b solution, reconstituted recon soln read the medication guide and instructions for use provided by your pharmacist before you start using this medication and each. Key difference interferon beta1a vs 1b in the context of modern pharmaceuticals, various types of drugs are synthesized using different technologies in order to develop effective therapeutics against different disease conditions. Simvastatin as addon therapy to interferon beta1a for. May 10, 20 subcutaneous interferon beta1a in pediatric multiple sclerosis. Interferon beta1a definition of interferon beta1a by. Interferon beta1b article about interferon beta1b by the. Most viruses are too small 1002,000 angstrom units to be seen with the light microscope and thus must be studied by electron microscopes. Interferon beta 1ainduced severe autoimmune hepatitis in. Interferon beta1a also interferon beta 1alpha is a cytokine in the interferon family used to treat multiple sclerosis ms. Interferon beta 1a is an immunologic adjuvant that is fda approved for the treatment of multiple sclerosis. Interferon beta1a is used to treat relapsing multiple sclerosis ms in adults. Rebif interferon beta1a dose, indications, adverse. It is produced by mammalian cells, while interferon beta1b is produced in modified e.
Interferon beta1a daviss drug guide for rehabilitation. Interferon beta1a also interferon beta 1alpha is a cytokine in the interferon family used to. A 41yearold man with a history of autologous stemcell transplantation received interferon beta1a for multiple sclerosis. Acquired hemophilia a has been attributed to interferon beta 1a 67 a. In a study in pregnant monkeys, administration of interferon beta during pregnancy resulted in an increased rate of abortion at doses greater than those used clinically lactation limited published literature has described the presence of interferon beta 1a products in human milk at low levels. Pdf recombinant human interferonbeta ifnb is a wellestablished treatment for multiple sclerosis ms. Rebidose autoinjector intended for subcutaneous sc injection.
Learn about avonex interferon beta1a, an fda approved treatment for relapsing multiple sclerosis ms. Nov, 2017 interferon beta 1a is utilized during the early stage of the disease condition for effective results, and interferon beta 1b is used during the second progressive stage of the disease condition. Interferon beta 1a is under investigation as a potential treatment for the covid19 coronavirus disease as of april, 2020. The formerly available lyophilized vial formulation of avonex is contraindicated in patients with a history of hypersensitivity to albumin human. Interferon beta1b is effective in relapsingremitting multiple sclerosis. It induced bdnf expression at middle concentrations. Interferon beta1a treatment in childhood and juvenileonset multiple sclerosis. Interferon beta1a may also be used for purposes not listed in this medication guide.
Common adverse reactions include flulike symptoms including chills, fever, myalgia, and asthenia. Difference between interferon beta1a and 1b compare the. Interferon beta 1b is manufactured by bacterial fermentation of a strain of escherichia coli that bears a genetically engineered plasmid containing the gene for human interferon. Acquired hemophilia a has been attributed to interferon beta1a 67 a. Avonex is contraindicated in patients with a history of hypersensitivity to natural or recombinant interferon beta. Apr 09, 2020 betaseron interferon beta 1b is a purified, sterile, lyophilized protein product produced by recombinant dna techniques. Interferon beta1a article about interferon beta1a by. Here, we report that recombinant human interferon beta 1a potently inhibits sars coronavirus replication in vitro. Food and drug administration fdaapproved firstline therapies for rms are interferon beta preparations, including intramuscular im interferon beta 1a avonex, b iogen idec, 2008, subcutaneous sc interferon beta 1a rebif, emd serono, 2009, sc interferon beta 1b betaseron, bayer healthcare pharmaceuticals, 2010, and sc interferon beta. Betaseron, extavia interferon beta 1b dosing, indications.
Interferon beta1a subcutaneous injection is used to treat adults with various forms of multiple sclerosis ms. Interferon beta 1a rebif treats relapsing multiple sclerosis in adults. Drug facts box interferon beta 1a and 1b for relapsingremitting ms rrms version 1. This division is based on the type of cell that produces the interferon and. Interferon beta 1a is produced by a method known as recombinant dna technology. These interferons have been classified into two types. Beta interferons and glatiramer acetate for treating multiple. A retrospective study article pdf available in journal of child neurology 287 may 20 with 159 reads how we measure reads. What are the possible side effects of interferon beta 1a.